science-product-detail
DOI :10.15419/bmrat.v8i5.671
Morphokinetic parameters comparison between euploid andaneuploid blastocysts
Phuong Thi Bich Le 1,2,*, Anh Hoang Le1,2, Loc Minh Tai Nguyen1,2, Vinh Quang Dang1,2
Background: Pre-implantation genetic testing for aneuploidy (PGT-A) has been using for years in embryoselection. However, this is an invasive method and may cause harm to the embryos. Therefore, time-lapse monitoring has been thought to be an alternative approach for embryo selection due to its efficiency. Up to now, several studies were investigating the relationship between the morphokinetic parameters and the embryo ploidy. However, the results are not consistent. This study aims to evaluate the correlation between morphokinetic parameters and PGT-A results.
Methods: This retrospective cohort study was conducted at IVFMD Phu Nhuan, My Duc Phu Nhuan Hospital, between September 2018 and June 2019. Patients undergoing PGT-A due to advanced maternal age, repeated implantation failure or recurrent miscarriage and having embryo cultured under time-lapse monitoring were included. Patients with the re-thawing embryo for PGT-A were not eligible. The time from insemination to the pronuclear appearing (tPN), the onset of two to eight-cell divisions (t2 to t8) and the duration of the second cell cycle (cc2, t3-t2) were observed.
Results: There were 39 patients included in the study, with mean age of 36.4 +/- 5.7 years. A total of 110 blastocysts were biopsied. Amongst them, 63 embryos (57.3%) were euploidy (group 1), and 47 embryos (42.7%) were aneuploidy (group 2). There was no significant difference between euploid, and aneuploid embryos regarding all morphokinetic parameters, including tPN, t2, t3, t4, t5, cc2, and t8 (7.2 +/- 1.5 hours vs. 7.4 +/- 1.6 hours; 25.0 +/- 2.8 hours vs. 25.6 +/- 3.2 hours; 35.8 +/- 3.6 hours vs. 36.9 +/- 3.3 hours; 37.5 +/- 4.4 hours vs. 38.3 +/- 4.3 hours; 49.2 +/- 5.52 hours vs. 49.9 +/- 6.2 hours; 10.7 +/- 2.6 hours vs. 11.2 +/- 1.7 hours; and 55.7 +/- 6.4 hours vs. 58.1 +/- 7.4 hours, respectively).
Conclusion: In this study, we found no difference in the morphokinetic parameters between euploid and aneuploid embryos
KEYWORDS:
aneuploidy, morphokinetic parameters, PGT-A, time-lapse system
Download
Similar articles
-
Review Predictive Value of AMH, FSH and AFC for Determining Ovarian Response in Vietnamese Women Undergoing Assisted Reproductive Technologies: A Prospective Study
[ TNL Vuong1*, MT Vo1 and MT Ho2,3 ]
Background: There are comparatively few data on the value of different ovarian response predictors in conjunction with...
-
Review Micronized progesterone plus dydrogesterone versus micronized progesterone alone for luteal phase support in frozen-thawed cycles (MIDRONE): a prospective cohort study
[ Lan N. Vuong 1,2,*, Toan D. Pham2, Khanh T.Q. Le2, Trung T. Ly2, Ho L. Le2, Diem T.N. Nguyen2, Vu N.A. Ho2, Vinh Q. Dang2, Tuan H. Phung2, Robert J. Norman3, Ben W. Mol4,5, and Tuong M. Ho2 ]
STUDY QUESTION
Does the addition of oral dydrogesterone to vaginal progesterone as luteal phase support improve pregnancy...
-
Review Top 10 priorities for future infertility research: an international consensus development study
[ J.M.N. Duffy 1,2,*, G.D. Adamson 3, E. Benson 4, S. Bhattacharya 5, S. Bhattacharya 5, M. Bofill 6, K. Brian 7, B. Collura 8, C. Curtis 9, J.L.H. Evers 10, R.G. Farquharson 11, A. Fincham 12, S. Franik 13, L.C. Giudice 14,15, E. Glanville 16, M. Hickey 17, A.W. Horne 18, M.L. Hull 19, N.P. Johnson 19, V. Jordan 6, Y. Khalaf 20, J.M.L. Knijnenburg 21, R.S. Legro 22, S. Lensen 17, J. MacKenzie 23, D. Mavrelos 24, B.W. Mol 25, D.E. Morbeck 6,26, H. Nagels 27, E.H.Y. Ng 28,29, C. Niederberger 30, A.S. Otter31, L. Puscasiu 32,33, S. Rautakallio-Hokkanen 12, L. Sadler 6,16, I. Sarris 1, M. Showell 27, J. Stewart 34, A. Strandell 35, C. Strawbridge 36, A. Vail 37, M. van Wely 38, M. Vercoe 27, N.L. Vuong 39, A.Y. Wang 40, R. Wang 25, J. Wilkinson 37, K. Wong 9, T.Y. Wong 16, C.M. Farquhar 6,27, and the Priority Setting Partnership for Infertility ]
STUDY QUESTION: Can the priorities for future research in infertility be identified?.
DOI:10.1093/humrep/deaa242
-
Review Live birth rate after human chorionic gonadotropin priming in vitro maturation in women with polycystic ovary syndrome
[ V. N. A. Ho1, T. D. Pham1, A. H. Le1, T. M. Ho1 and L. N. Vuong1,2* ]
Background
In vitro maturation (IVM) has some advantages over conventional in vitro fertilization (IVF), particul... -
Review Top 10 priorities for future infertility research: an international consensus development study
[
J.M.N. Duffy, G.D. Adamson, E. Benson, S. Bhattacharya, S. Bhattacharya, M. Bofill, K. Brian, B. Collura, C. Curtis, J.L.H. Evers, R.G. Farquharson, A. Fincham, S. Franik, L.C. Giudice, E. Glanville, M. Hickey, A.W. Horne, M.L. Hull, N.P. Johnson, V. Jordan, Y. Khalaf, J.M.L. Knijnenburg, R.S. Legro, S. Lensen, J. MacKenzie, D. Mavrelos, B.W. Mol, D.E. Morbeck, H. Nagels, E.H.Y. Ng, C. Niederberger, A.S. Otter, L. Puscasiu, S. Rautakallio-Hokkanen, L. Sadler, I. Sarris, M. Showell, J. Stewart, A. Strandell, C. Strawbridge, A. Vail, M. van Wely, M. Vercoe, N.L. Vuong, A.Y. Wang, R. Wang, J. Wilkinson, K. Wong, T.Y. Wong, C.M. Farquhar and the Priority Setting Partnership for Infertility
]
ABSTRACT
Study Question<...