Impact of Polycystic Ovary Syndrome Phenotypes on in Vitro Fertilization Outcomes in Vietnamese Women: A Secondary Analysis of a Randomized Controlled Trial
Vu N.A. Ho1,2, Toan D. Pham1,2, Hieu L.T. Hoang1 , Lan N. Vuong1,2,3
Background: Polycystic ovary syndrome (PCOS) is diagnosed when ≥2 of the following symptoms are present: ovulation disorder (OD), hyperandrogenism (HA), and polycystic ovary morphology (PCO). Clinical features of PCOS are heterogeneous and there are four clinical phenotypes: A (OD + HA + PCO); B (HA + OD); C (HA + PCO); and D (OD + PCO). Women with a PCOS phenotype that includes severe HA are at increased risk for pregnancy complications. There are currently no data on impact of PCOS phenotypes on in vitro fertilization (IVF) outcomes in Vietnamese women. This study investigated the association between PCOS phenotypes and IVF outcomes.
Methods: This is a secondary analysis of a randomized controlled trial conducted in patients with PCOS undergoing IVF at IVFMD, My Duc Hospital, Ho Chi Minh City, Vietnam between January 2018 and April 2019. The primary outcome was live birth rate
Results: A total of 192 patients were included, of whom 33 patients had phenotype A (17.2%) and 159 had phenotype D (82.8%); no patients had phenotype B or C. Body mass index was significantly higher in patients with phenotype A than D (25.36 ± 4.78 versus 22.08 ± 3.21, p = 0.001). There were no differences in laboratory and pregnancy outcomes between patients with phenotypes A and D. The live birth rate was lower in patients with phenotype A versus D, but the between-group difference did not reach statistical significance (33.3% vs. 42.8%, p = 0.419). Conclusions: The common PCOS phenotypes in Vietnamese women with infertility were A and D. No impact of PCOS phenotypes on IVF treatment outcomes was detected in this secondary analysis; larger studies are needed to confirm these findings.
In Vitro Fertilization; Polycystic Ovary Syndrome; Ovulation Disorder; Hyperandrogenism; Live Birth
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[ Sandro C Esteves1, Hakan Yarali2,3, Lan N Vuong4,5,6, José F Carvalho7, İrem Y Özbek2, Mehtap Polat2, Ho L Le4,5, Toan D Pham4,5, Tuong M Ho4,5 ]
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[ J.M.N. Duffy 1,2,*, G.D. Adamson 3, E. Benson 4, S. Bhattacharya 5, S. Bhattacharya 5, M. Bofill 6, K. Brian 7, B. Collura 8, C. Curtis 9, J.L.H. Evers 10, R.G. Farquharson 11, A. Fincham 12, S. Franik 13, L.C. Giudice 14,15, E. Glanville 16, M. Hickey 17, A.W. Horne 18, M.L. Hull 19, N.P. Johnson 19, V. Jordan 6, Y. Khalaf 20, J.M.L. Knijnenburg 21, R.S. Legro 22, S. Lensen 17, J. MacKenzie 23, D. Mavrelos 24, B.W. Mol 25, D.E. Morbeck 6,26, H. Nagels 27, E.H.Y. Ng 28,29, C. Niederberger 30, A.S. Otter31, L. Puscasiu 32,33, S. Rautakallio-Hokkanen 12, L. Sadler 6,16, I. Sarris 1, M. Showell 27, J. Stewart 34, A. Strandell 35, C. Strawbridge 36, A. Vail 37, M. van Wely 38, M. Vercoe 27, N.L. Vuong 39, A.Y. Wang 40, R. Wang 25, J. Wilkinson 37, K. Wong 9, T.Y. Wong 16, C.M. Farquhar 6,27, and the Priority Setting Partnership for Infertility ]
STUDY QUESTION: Can the priorities for future research in infertility be identified?.
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[ Anh N. Ha1,2, Toan D. Pham2, Lan N. Vuong1,2,3 ]
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[ Panagiotis Drakopoulos1,2, Thi Ngoc Lan Vuong3,4, Ngoc Anh Vu Ho4, Alberto Vaiarelli1, Manh Tuong Ho4,5, Christophe Blockeel1,2,6, Michel Camus2, Anh Tuan Lam4, Arne van de Vijver1,2, Peter Humaidan8, Herman Tournaye1,2, and Nikolaos P. Polyzos1,2,7,8,* ]
Does administration of corifollitropin alfa followed by highly purified (hp) HMG result in higher...
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