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DOI: 10.1142/S266131821950018X

Live Birth Rate After Transfer of Fresh or Frozen Poor Quality Day-3 Embryos Only

Lan N. Vuong1,2,*, Toan D. Pham2, Bao G. Huynh2, Quynh N. Nguyen2, Tuong M. Ho2, Robert J. Norman3, Ben W. Mol4

  1. Department of Obstetrics and Gynaecology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam
  2. IVFMD, My Duc Hospital, Ho Chi Minh City, Vietnam
  3. University of Adelaide and Fertility SA, Adelaide, Australia
  4. Department of Obstetrics and Gynaecology, School of Medicine, Monash University, Melbourne, Australia
Abstract

Background:

Embryo quality is an important predictor of successful outcome in in vitro fertilization (IVF). However, current knowledge on the live birth rate afer transfer of poor quality embryos is limited. This study investigated the live birth rate afer transfer of only poor quality day-3 embryos in women undergoing IVF.

Methods:

This retrospective study included 153 couples who underwent IVF at IVFMD, My Duc Hospital, Ho Chi Minh City, Vietnam between June 2014 and January 2017 and had only poor quality day-3 embryos available for fresh (n = 102) or frozen (n 51) transfer. The control group included patients who had transfer of one good embryo (n = 64). Embryos were rated using the Istanbul criteria.

Results:

In the poor quality embryo group, the mean number of oocytes retrieved and number of embryos were 7.5 ± 4.4 and 1.8 ± 0.9, respectively. Mean number of embryos transferred was 1.6 ± 0.5 in the fresh transfer group and 2.0 ± 0.2 in the freeze-only group. Live births did occur afer transfer of poor quality embryos, but the implantation, clinical pregnancy and live birth rates were signifcantly lower than afer fresh or frozen transfer of a single good quality embryo (9.5 vs. 26.6%, p 0.001; 13.7 vs. 26.6%, p 0.001; and 7.2 vs. 18.8%, p = 0.02, respectively).

Conclusions:

Live birth was achieved afer transfer of only poor quality embryos in women undergoing IVF. This suggests that transfer of poor quality embryos could be an option when higher grade embryos are not available, afer the chances of live birth have been discussed with the patient.

KEYWORDS:

In Vitro Fertilization; Intracytoplasmic Sperm Injection; Poor Embryos; Live Birth

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