Is Intracytoplasmic Sperm Injection the Solution for all in Unexplained Infertility?
Intracytoplasmic sperm injection (ICSI) was first introduced as a supplemental method to conventional in vitro fertilization (c-IVF) for couples with severe male factor infertility to overcome the poor fertilization rate, while its indications expanded in current clinical practice and gained worldwide popularity. However, ICSI is invasive and crosses all natural barriers, raising several unresolved concerns regarding procedure-dependent and procedure-independent risks, as well as the characteristic of being labor-intensive and more expensive than c-IVF. This review is aimed to draw readers' attention, to the widespread use of ICSI worldwide, with its effectiveness in different indications of infertility, especially in those with unexplained infertility, as well as the cost-effectiveness of the ICSI-for-all strategy. Also, we covered current evidence on the short- and long-term safety of children born thanks to ICSI-aided conception. Further well-designed, adequately powered, and randomized controlled clinical trials are absolutely needed to arrive at a consensus on the use of ICSI over c-IVF in different populations.
intracytoplasmic sperm injection - unexplained infertility - assisted reproductive technology - conventional in vitro fertilization - infertility
Review Morphokinetic parameters comparison between euploid andaneuploid blastocysts
[ Phuong Thi Bich Le 1,2,*, Anh Hoang Le1,2, Loc Minh Tai Nguyen1,2, Vinh Quang Dang1,2 ]
Background: Pre-implantation genetic testing for aneuploidy (PGT-A) has been using for years in embry...
Review Shortcomings of an unphysiological triggering of oocyte maturation using human chorionic gonadotropin
[ Claus Yding Andersen, D.M.Sc.a,b, Thomas Kelsey, Ph.D.c, Linn Salto Mamsen, Ph.D.a, and Lan Ngoc Vuong, M.D., Ph.D.d,e,f ]
Final maturation of follicles has, in connection with ovarian stimulation and infertility treatment, traditionally bee...
Review A protocol developing, disseminating and implementing a core outcome set for infertility
[ J.M.N. Duffy1,2,*, S. Bhattacharya3, C. Curtis4,5, J.L.H. Evers6, R.G. Farquharson7, S. Franik8, Y. Khalaf9, R.S. Legro10, S.Lensen11, B.W. Mol12, C. Niederberger13, E.H.Y. Ng14, S. Repping15, A. Strandell16, H.L. Torrance17, A. Vail18, M. van Wely15, N.L. Vuong19, A.Y. Wang20, R. Wang21, J. Wilkinson18, M.A. Youssef22, and C.M. Farquhar11, on behalf of COMMIT: Core Outcomes Measures for Infertility Trials ]
We aim to produce, disseminate and implement a core outcome set for future infertility research.<...
Review Selecting euploid embryo for transfer by preimplantation genetic testing for aneuploidy improved clinical outcomes in patients with advanced maternal age
[ Le Thi Bich Phuong1,2, Vo Nguyen Thuc1,2, Pham Thieu Quan1,2, Le Hoang Anh1,2, Dang Quang Vinh1,2, Nguyen Thi Thuong Huyen3 ]
ObjectivesThis study aimed to investigate whether selecti...
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- Review In-vitro maturation of oocytes versus conventional IVF in women with infertility and a high antral follicle count: a randomized non-inferiority controlled trial [ Lan N. Vuong1,2, Vu N.A. Ho2, Tuong M. Ho2, Vinh Q. Dang2, Tuan H. Phung2, Nhu H. Giang2, Anh H. Le2, Toan D. Pham2, Rui Wang3, Johan Smitz4, Robert B. Gilchrist5, Robert J. Norman6,7, and Ben W. Mol3 ]