Is Intracytoplasmic Sperm Injection the Solution for all in Unexplained Infertility?
Intracytoplasmic sperm injection (ICSI) was first introduced as a supplemental method to conventional in vitro fertilization (c-IVF) for couples with severe male factor infertility to overcome the poor fertilization rate, while its indications expanded in current clinical practice and gained worldwide popularity. However, ICSI is invasive and crosses all natural barriers, raising several unresolved concerns regarding procedure-dependent and procedure-independent risks, as well as the characteristic of being labor-intensive and more expensive than c-IVF. This review is aimed to draw readers' attention, to the widespread use of ICSI worldwide, with its effectiveness in different indications of infertility, especially in those with unexplained infertility, as well as the cost-effectiveness of the ICSI-for-all strategy. Also, we covered current evidence on the short- and long-term safety of children born thanks to ICSI-aided conception. Further well-designed, adequately powered, and randomized controlled clinical trials are absolutely needed to arrive at a consensus on the use of ICSI over c-IVF in different populations.
intracytoplasmic sperm injection - unexplained infertility - assisted reproductive technology - conventional in vitro fertilization - infertility
Review Clinical parameters of ovarian hyperstimulation syndrome following different hormonal triggers of oocyte maturation in IVF treatment
[ A. Abbara1, R. Islam2, S.A. Clarke1, L. Jeffers1, G. Christopoulos2, A.N. Comninos1, R. Salim2, S.A. Lavery2, T.N.L. Vuong3,4, P. Humaidan5, T.W. Kelsey6, G.H. Trew2, W.S. Dhillo1 ]
Ovarian hyperstimulation syndrome (OHSS) is a serious iatrogenic condition, predominantly related to th...
Review Follicle Size on Day of Trigger Most Likely to Yield a Mature Oocyte
[ Ali Abbara1, Lan N. Vuong2,3, Vu N. A. Ho3, Sophie A. Clarke1, Lisa Jeffers1, Alexander N. Comninos1, Rehan Salim4, Tuong M. Ho3, Tom W. Kelsey5, Geoffrey H. Trew4, Peter Humaidan6and Waljit S. Dhillo1 ]
Objective: To identify follicle sizes on the day of trigger most likely to yield a mature oocyte following hCG, GnRH a...
Review Standardizing definitions and reporting guidelines for the infertility core outcome set: an international consensus development study
[ J M N Duffy 1 2, S Bhattacharya 3, S Bhattacharya 3, M Bofill 4, B Collura 5, C Curtis 6 7, J L H Evers 8, L C Giudice 9 10, R G Farquharson 11, S Franik 12, M Hickey 13, M L Hull 14, V Jordan 4, Y Khalaf 15, R S Legro 16, S Lensen 13, D Mavrelos 17, B W Mol 18, C Niederberger 19, E H Y Ng 20 21, L Puscasiu 22, S Repping 23 24, I Sarris 1, M Showell 25, A Strandell 26, A Vail 27, M van Wely 23, M Vercoe 25, N L Vuong 28, A Y Wang 29, R Wang 18, J Wilkinson 27, M A Youssef 30, C M Farquhar 4 25, Core Outcome Measure for Infertility Trials (COMMIT) initiative ]
Study question: Can consensus definitions for the core outcome set for inferti...
Review A randomised controlled trial to clinically validate follitropin delta in its individualised dosing regimen for ovarian stimulation in Asian IVF/ICSI patients
[ Jie Qiao 1,2, Yunshan Zhang3 , Xiaoyan Liang4 , Tuong Ho5 , Hong-Yuan Huang6 , Sung-Hoon Kim7 , Marie Goethberg8 , Bernadette Mannaerts9 , and Joan-Carles Arce 9,*, on behalf of the Asian Follitropin Delta Phase 3 Trial (GRAPE) Group†
Review Predictive Value of AMH, FSH and AFC for Determining Ovarian Response in Vietnamese Women Undergoing Assisted Reproductive Technologies: A Prospective Study
[ TNL Vuong1*, MT Vo1 and MT Ho2,3 ]
Background: There are comparatively few data on the value of different ovarian response predictors in conjunction with...