Reference Intervals of Thyroid Function Tests in First Trimester Vietnamese Pregnant Women
Background: Although TSH suppression by elevated β-hCG is essentially seen during first trimester, differences in TSH reference ranges between various countries have been reported. Physiologic changes during pregnancy may also influence FT4 assays. This study aims to establish method-specific reference intervals (RIs) of TSH, FT4, and FT3 in Vietnamese, first trimester pregnant women.
Methods: This cross-sectional study was conducted at My Duc Hospital, Ho Chi Minh, Vietnam. Women with singleton pregnancies in the first trimester and conceived naturally were included. Those with a history of thyroid disease, positive thyroid-specific autoantibodies, diffuse goiter or one thyroid nodule > 10 mm in size or ≥ 2 nodules detected by ultrasound, and taking medications affecting thyroid function were excluded. Serum TSH, FT4, and FT3 were measured by chemiluminescent detection technology on the Access 2 Immunoassay System (Beckman Coulter, Inc., USA). Intra- and interassay coefficients of variations (CV) were 3.6% and 4.4% for TSH, 5.4% and 6.1% for FT4, 6.6%, and 6.0% for FT3, respectively. The 2.5th and 97.5th percentiles were used to determine RIs.
Results: Between August 1, 2017, to December 1, 2018, there were 876 pregnant women who fulfilled inclusion and exclusion criteria. They had a mean age of 30.1 years, an average BMI of 21.3 kg/m2, and 77.3% of them were primigravida. The RIs for TSH, FT4 and FT3 were 0.17 - 2.35 mIU/L, 0.67 - 1.11 ng/dL and 2.82 - 3.90 pg/mL, respectively.
Conclusions: Established RIs for TSH, FT4, and FT3 in Vietnamese women would help to reduce the misdiagnosis of gestational thyroid disorders.
Review IVF Transfer of Fresh or Frozen Embryos in Women without Polycystic Ovaries
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Among women who are undergoing in vitro fertilization (IVF), the transfer of frozen embryos has been s...
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Gonadotropins have been recommended to improve ovula...
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The primary aim of this study was to identify the level of stress and the stressors having an impact on nurse...
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Oocyte in vitro maturation (IVM) is an assisted reproductive technology designed to obtain mature oocytes following cu...
Review Development of children born from freeze-only versus fresh embryo transfer: follow-up of a randomized controlled trial
[ Lan Ngoc Vuong, M.D., Ph.D.a,b,c, Trung Thien Ly, M.D.b, Nghia An Nguyen, M.D., Ph.D.d, Loc Minh Tai Nguyen, M.Sc.c, Xuyen Thi Ha Le, M.D.b, Tien Khac Le, M.D.b, Khanh Tuan Quoc Le, M.D.b, Thanh Van Le, M.D.b, Minh Hoang Nhat Nguyen, M.Sc.c, Vinh Quang Dang, M.D.b,c, Robert J. Norman, M.D.e,f, Ben Willem Mol, M.D., Ph.D.g, and Tuong Manh Ho, M.D.b,c ]
To compare the longer-term development outcomes in chi...