Support: (+84) 28 7308 5885 - (Ext) 303 or 310

Live birth after vitrification of oocytes from capacitation in vitro maturation

doi: 10.1007/s10815-024-03200-y. Epub 2024 Jul 11.

Published: 11 July, 2024

Xuyen T H Le 1 2Dung P Nguyen 3 4Thao T Nguyen 3 4Tien K Le 3 4Lan N Vuong 5Tuong M Ho 6 4

Authors information

1IVMFD Phu Nhuan, My Duc Phu Nhuan Hospital, 43R/2-4 Ho Van Hue, Phu Nhuan District, Ho Chi Minh City, Vietnam. bsxuyen.lth@myduchospital.vn.

2HOPE Research Center, My Duc Hospital, Ho Chi Minh City, Vietnam. bsxuyen.lth@myduchospital.vn.

3IVMFD Phu Nhuan, My Duc Phu Nhuan Hospital, 43R/2-4 Ho Van Hue, Phu Nhuan District, Ho Chi Minh City, Vietnam.

4HOPE Research Center, My Duc Hospital, Ho Chi Minh City, Vietnam.

5Department of Obstetrics and Gynaecology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.

6IVFMD, My Duc Hospital, Ho Chi Minh City, Vietnam.

Abstract

Female fertility preservation is a rapidly growing field in medicine. Oocyte cryopreservation and assisted reproductive technique with vitrified-warmed oocytes have been successful with in vivo matured oocytes after conventional ovarian stimulation protocols. The use of in vitro matured oocytes after vitrification and warming has been limited. Capacitation in vitro maturation (CAPA-IVM) represents the latest refinement of IVM protocols and provides in vitro matured oocytes with improved competence. This case report describes the first successful live birth following oocyte vitrification from a CAPA-IVM cycle. This milestone achievement holds a significant promise to expand fertility preservation options and improve accessibility for women wishing to cryopreserve their eggs for future use.

Keywords: CAPA-IVM; Egg freezing; In vitro maturation; Oocyte cryopreservation.