Support: (+84) 28 7308 5885 - (Ext) 303 or 310

The POSEIDON Criteria and Its Measure of Success Through the Eyes of Clinicians and Embryologists

DOI: 10.3389/fendo.2019.00814

Front Endocrinol (Lausanne). 2019 Nov 20;10:814 – 2019-11-20

Esteves SC1Alviggi C2Humaidan P3,4Fischer R5Andersen CY6Conforti A2Bühler K7,8Sunkara SK9Polyzos NP10Galliano D11Grynberg M12Yarali H13Özbek IY13Roque M14Vuong LN15,16Banker M17Rienzi L18Vaiarelli A18Cimadomo D18Ubaldi FM18

Published: 20 November, 2019

Author information


This article represents a viewpoint on the POSEIDON criteria by a group of clinicians and embryologists. Its primary objective is to contextualize the Poseidon criteria and their metric of success for the relevant Frontiers Research Topic “POSEIDON’s Stratification of Low Prognosis Patients in ART: The WHY, the WHAT, and the HOW”. “Low prognosis” relates with reduced oocyte number, which can be associated with low or sometimes a normal ovarian reserve and is aggravated by advanced female age. These aspects will ultimately affect the number of embryos generated and consequently, the cumulative live birth rate. The novel system relies on female age, ovarian reserve markers, ovarian sensitivity to exogenous gonadotropin, and the number of oocytes retrieved, which will both identify the patients with low prognosis and stratify such patients into one of four groups of women with “expected” or “unexpected” impaired ovarian response to exogenous gonadotropin stimulation. Furthermore, the POSEIDON group introduced a new measure of clinical success in ART, namely, the ability to retrieve the number of oocytes needed to obtain at least one euploid blastocyst for transfer in each patient. Using the POSEIDON criteria, the clinician can firstly identify and classify patients who have low prognosis in ART, and secondly, aim at designing an individualized treatment plan to maximize the chances of achieving the POSEIDON measure of success in each of the four low prognosis groups. The novel POSEIDON classification system is anticipated to improve counseling and management of low prognosis patients undergoing ART, with an expected positive effect on reproductive success and a reduction in the time to live birth.


ART calculator; POSEIDON criteria; assisted reproductive technology; blastocyst; low prognosis; oocyte; ovarian stimulation; poor ovarian response